Outcomes Associated With Antimicrobial De-escalation of Treatment for Healthcare-Associated Pneumonia (HCAP) Within the Veterans Healthcare Administration

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Outcomes Associated With Antimicrobial De-escalation of Treatment for Pneumonia Within the Veterans Healthcare Administration

De-escalation, an antimicrobial stewardship concept, involves narrowing broad-spectrum empiric antimicrobial therapy based on clinical data. Current health outcomes evidence is lacking to support de-escalation. Studying Veterans Healthcare Administration pneumonia patients, de-escalation was associated with improved length of stay without affecting 30-day readmission or 30-day Clostridium diffi...

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Practice patterns for antibiotic de-escalation in culture-negative healthcare-associated pneumonia

BACKGROUND Published guidelines for the treatment of healthcare-associated pneumonia (HCAP) recommend initial broad-spectrum antibiotics with appropriate de-escalation based on culture results. Guideline recommendations are based on data from intubated patients, in whom cultures are easily obtained. The approach to antibiotic de-escalation for culture-negative patients has not been addressed. C...

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ژورنال

عنوان ژورنال: Open Forum Infectious Diseases

سال: 2016

ISSN: 2328-8957

DOI: 10.1093/ofid/ofw172.676